Protein having a vascularization inhibitory effect and a method for production thereof and a method for producing angiostatin

摘要

A protein derived from human plasminogen which has amino acids 355-791 of human plasminogen are purified. A method for purifying said protein and angiostatin comprises the steps of fractionating said protein by Lysine-Sepharose chromatography to separate plasminogen in Form 1 and Form 2 and applying separately each of them to a Lysine-Sepharose column in order.