| 摘要 |
<p>It has been discovered that neuromodulators may be used in the treatment of severe carbon monoxide (CO) poisoning. These neuromodulators include those that prevent the release of excitatory neurotransmitters, such as riluzole, and molecules that competitively and non-competitively antagonize glutamate receptors, particularly of the NMDA type. Another class of neuromodulators that are useful in the treatment of carbon monoxide poisoning includes adenosine and its derivatives that have a binding affinity for the A1 or A2 receptors, such as N-cyclochloro-P-adenosine (CCPA). Also included are molecules that modulate adenosine transport and metabolism by either inhibiting adenosine deaminase or adenosine kinase or nucleoside transporters. Another effective class of neuromodulators includes arginine derivative that inhibit nitric oxide systhetase (NOS), such as L-nitro-arginine-methyl-ester (L-NAME). Another class of therapeutic drugs includes antioxidants such as dimethyl sulfoxide (DMSO). Another class of neuroprotective agents that are effective in treating carbon monoxide poisoning includes molecules that inhibitor poly(ADP-ribose) polymerase (PARP), such as 3-aminobenzamide and 5-aminoisoquinolinone. Finally, another class of neuromodulatory agents includes molecules such that open potassium channels, particularly of the maxi K+ channel type, such as BMS 204352.</p> |
