| 摘要 |
A variant blood coagulation component, which is substantially homologous in amino acid sequence to wild-type blood coagulation component capable of expressing anticoagulant activity in the protein C-anticoagulant system of blood and selected from protein C (PC), activated protein C (APC) and protein S (PS). The variant component is capable of expressing an anticoagulant activity, which is enhanced in comparison with the anticoagulant activity expressed by the corresponding wild-type blood coagulation component, and the variant component differing from the respective wild-type component, in that it contains in comparison with the wild-type component at least one amino acid residue modification in its amino acid residue sequence.
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