2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors

摘要

A compound of formula Iin whichX means hydrogen or halogen,Y means -NR3- or -N=,R1 and R2 are the same or different and mean hydrogen, C1-C6 alkyl, nitro, halogen, the group -NR8R9, -O-C1-4 alkyl, -CF3, OH or C1-6 alkanoyloxy,R3 means hydrogen, the group -CO-R10, C1-6 alkyl or C3-7 cycloalkyl,R4 means optionally substituted C1-C6 alkyl,R5 means hydrogen orR4 and R5 together mean oxygen,R6 means C1-4 alkyl,R8 and R9 are the same or different and mean hydrogen, C1-C6 alkyl or -CO-C1-6 alkyl,R10 means hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C6-10 aryl, the group -NR11R12, -O-C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or -O-C3-7 cycloalkyl,R11 and R12 are the same or different and mean hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C6-10 aryl and-C...C... means a double bond or single bondsor an isomer or physiologically compatible salt thereof with the proviso that the compound is not 1-(3-chlorophenyl)-4-methyl-8-methoxy, 5H-2,3-benzodiazepine.