| 摘要 |
Conformationally constrained compounds which mimic the secondary structure o f reverse-turn regions of biologically active peptides and proteins having structure (I) are disclosed, wherein A, R1, R2, R2a, R3, R3a and R4 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti- inflammatory agents. Libraries containing the compounds of this invention ar e also disclosed, as well as methods for screening the same to identify biologically active members.
|
