TRANSGENIC ANIMAL MODEL FOR NEURODEGENERATIVE DISEASES

摘要

The present application refers to a mouse parkin2 DNA- and protein sequence, containing mutations or deletions causing Parkinson's disease in a human if occurring in the according human sequence, the construction of a transgenic non-human animal containing such a mutated DNA sequence and therefore expressing no or a less active or non-active parkin protein as well as the u se of this transgenic animal as a model for neurodegenerative diseases.