MOSAIC CONSERVED REGION HIV IMMUNOGENIC POLYPEPTIDES

摘要

Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.

主权项

1. An isolated immunogenic polypeptide comprising two or more of the amino acid sequences set forth as SEQ ID NOs: 1-18, or amino acid sequences having at least 95% identity to the amino acid sequence of any one of SEQ ID NOs: 1-18.