| 摘要 |
medicine. SUBSTANCE: invention relates to preparing compositions based on perfluorocarbon emulsions used as artificial blood substitutes, contrasting agents and media for organs conservation and storage. Invention involves preparing blood substituting compositions based on perfluorocarbon emulsions with decreased degree of adverse effects and transient presence of perfluoroorganic compounds in body. For preparing blood substituting compositions mixtures consisting of 2, 3, 4 perfluoroorganic compounds are used: perfluorodecaline, perfluorooctyl-bromide, perfluoromethylcyclo-hexylpiperidine, perfluorotributylamine taken in the different ratios and emulsified with proxanol (or phospholipids) followed by addition of electrolyte solution to prepared emulsion up to achievement of perfluorocarbons concentration from 1% to 20% and proxanol from 0.4% to 4.8%. EFFECT: improved medical-biological and physical-chemical indices of blood substituting compositions, broadened area of perfluorocarbon blood substitutes using. 5 cl, 1 tbl, 5 ex |
