FOLLISTATIN ANTAGONISTS

摘要

Follistatin antagonists are disclosed. The antagonists are polypeptides that include a non-activin-binding FS N-Domain or non-activin-binding FLRG N-Domain; and a heparin sulfate-binding moiety; wherein the tryptophan residue (W) at position 4 or 36 of the non-activin-binding N-Domain is substituted by a non-aromatic amino acid such as alamine. An example of a heparin sulfate-binding moiety is Domains I-III of human follistatin.