| 发明名称 |
A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3-(4-[2-(PIPERIDIN-1-YL)ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE |
| 摘要 |
The present invention is directed to a novel crystalline hydrate of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride and uses for same, including inhibition of disease states associated with estrogen deprivation including cardiovascular disease, hyperlipidemia, and osteoporosis; and inhibition of other pathological conditions such as endometriosis, uterine fibrosis, estrogen-dependent cancer (including breast and uterine cancer), prostate cancer, benign prostatic hyperplasia, CNS disorders including Alzheimer's disease, prevention of breast cancer, and up-regulating ChAT.
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| 申请公布号 |
WO0109116(A2) |
申请公布日期 |
2001.02.08 |
| 申请号 |
WO2000US16333 |
申请日期 |
2000.07.17 |
| 申请人 |
ELI LILLY AND COMPANY;BUSH, JULIE, KAY;CONRAD, PRESTON, CHARLES;FLOM, MERLYN, GERARD;LUKE, WAYNE, DOUGLAS |
发明人 |
BUSH, JULIE, KAY;CONRAD, PRESTON, CHARLES;FLOM, MERLYN, GERARD;LUKE, WAYNE, DOUGLAS |
| 分类号 |
C07D409/12;A61K31/4535;A61K31/566;A61K31/567;A61K31/57;A61K38/22;A61K45/00;A61K45/06;A61P3/06;A61P5/32;A61P9/00;A61P15/00;A61P19/08;A61P19/10;A61P25/00;A61P25/28;A61P35/00;A61P43/00;C07D333/64;(IPC1-7):C07D333/64;A61K31/453 |
主分类号 |
C07D409/12 |
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