| 摘要 |
A new casein is disclosed isolated from the milk of Korean cattle with a beta-casein A1H genotype. Amino acid sequence analysis of the casein revealed a length of 209 amino acids, where, in comparison to the more conventional beta-casein variant A2, at amino acid position 25, Arg is replaced by Cys, at position 88, Leu is replaced by Ile, at position 117, Gln is replaced by Glu, at position 175, Glu is replaced by Gln, and at position 195, Gln is replaced by Glu. The new casein variant disclosed can be mass produced by the selective breeding of individual bovines to produce large quantities of milk containing the new casein variant. In one example of such breeding, a female calf was born that subsequently produced the inventive casein at a yield of 4.5 kg per day. The new casein gene can be detected DNA hybridization analysis in bovines secreting the new casein. The new casein increases the absorption of casein from the small intestine about 5% in the upper region of the small intestine and about 20% in the lower region of the small intestine. Thus, this new casein can be formulated in to foodstuffs, such as infant formula, dairy products, and to treat diseases, such as osteoporosis and anemia. Further, the new casein can also be formulated into skin and hair products.
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