SUBSTITUTED TRIAZOLINONES, TRIAZOLINETHIONES AND TRIAZOLINIMINES AS ANGIOTENSIN II ANTAGONISTS

摘要

There are disclosed new substituted triazolinone, triazolinethione, and triazolinimine compounds which are useful as angiotensin II antagonists. These compounds have the general formula: wherein: R1 is (a) -CO2R4, (b) -SO3R5, (c) -NHSO2CF3, (d) -PO(OR5)2, (e) -SO2-NH-R9, (f) -CONHOR5, (g) -SO2NH-heteroaryl, (h) -CH2SO2NH-heteroaryl, (i) -SO2NHCOR23, (j) -CH2SO2NHCOR23, (k)-CONHSO2R23, (l)-CH2CONHSO2R23, (m)-NHSO2NHCOR23, (n)-NHCONHSO2R23, <IMGS> (s) -CONHNNSO2CF3 <IMGS> wherein: heteroaryl is an unsubstituted, monosubstituted or disubstituted 5- or 6-membered aromatic ring which contains from 1 to 3 heteroatoms selected from the group consisting of O, N and S and wherein the substituents are members selected from the group consisting of -OH, -SH, C1-C4-alkyl, C1-C4-alkoxy, -CF3, halo (Cl, Br, F, I), -NO2, -CO2H, -CO2-C1-C4-alkyl, -NH2, -NH (C1-C4-alkyl) or -N(C1-C4-alkyl)2.