发明名称 |
PREVENTION AND TREATMENT OF AMYLOID-ASSOCIATED DISORDERS |
摘要 |
The present invention provides assays to identify compounds that affect microglial cell activation, and specifically assays to identify compounds that affect secretion of cytokines from these microglial cells by modulating PGE2-mediated activity. The assays of the invention include assays for testing microglial cell activation by contacting microglia with compounds that modulate beta -amyloid PGE2-mediated activation, which can be identified by cellular activity such as secretion of cytokines, e.g., TNF- alpha and IL-1 alpha . The effect of the candidate compound can be determined by comparing the effect with a control culture which is not contacted with the compound, or by comparing the effect with a standardized profile.
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申请公布号 |
WO0102855(A1) |
申请公布日期 |
2001.01.11 |
申请号 |
WO2000US18227 |
申请日期 |
2000.06.30 |
申请人 |
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发明人 |
HYSLOP, PAUL, ANDREW;MILLER, FOY, DEAN;HIGGINS, LINDA, S.;CATALANO, ROSANNE;CORDELL, BARBARA;PUCHACZ, ELZBIETA |
分类号 |
A61K45/00;A61P25/28;C12Q1/02;G01N33/15;G01N33/50;G01N33/68;(IPC1-7):G01N33/50 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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