| 摘要 |
<p>Aminobenzoic acid derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof which are usable as VEGF receptor antagonists, in particular, remedies for diseases in which VEGF participates wherein R1 represents hydrogen, C¿1-6? alkyl, etc.; R?2¿ represents hydrogen, C¿1-6? alkyl, etc.; R?3¿ represents C¿8-25? alkyl, etc.; R?4¿ represents hydrogen, OR9 or CO¿2R?10 (wherein R?9 and R10¿ represent each hydrogen or C¿1-6? alkyl); A represents S(O)qR?15¿ [wherein q is 0, 1 or 2; and R15 represents C¿1-6? alkyl, phenyl (C1-3 alkyl) or (CH2)mOR?16¿ (wherein m is 2 or 3; and R16 represents hydrogen or methoxymethyl)], etc.; X represents O, a single bond, CH=CH or NR27 (wherein R27 represents hydrogen or t-butoxycarbonyl); Y represents O, CONH, NHCO or NR28 (wherein R28 represents hydrogen or t-butoxycarbonyl); and n is an integer of from 0 to 15.</p> |
