| 摘要 |
The present invention relates to a process for preparing biodegradable microspheres containing physiologically active agents. Particularly, the present invention relates to the process comprised the following steps (1) to prepare a polymer solution containing physiologically active agents wherein a biodegradable polymer is dissolved in a water-soluble organic solvent and physiologically active agents are dissolved or suspended to it; (2) to form a O/O type emulsion by emulsifying the polymer solution into a water soluble alcohol which contains an emulsion stabilizer; and (3) to extract the organic solventS and alcohol by adding the emulsion into a neutral or an alkaline aqueous solution to educe the microspheres. The process of the present invention is effective for producing the microspheres having a uniform size which arm congenital to a living body and has an excellent inclusion efficiency. So, the microspheres prepared by the process of the present invention are used for a drug delivery system. |
