| 摘要 |
The imidazo[1,2-a]pyridine-3-acetamide derivatives of formula (I) are used for the treatment of Parkinson's disease, parkinsonian syndromes, extrapyramidal syndromes, obsessive-compulsive disorder and syndromes, and frontal and subcortical dementias. In formula (I): Y represents a hydrogen or halogen atom or a C1 - 4 alkyl group; A represents naphthyl or C6 H3 X1 X2, wherein each of X1 and X2 independently of one another is a hydrogen or halogen atom, a C1 - 4 alkoxy group, a C1 - 6 alkyl group or CF3, CH3S- , CH3 SO2 - or -NO2 ; and each of R1 and R2 independently of one another represents; a hydrogen atom, a straight or branched C1 - 5 alkyl group which is unsubstituted or substituted by one or more halogen atoms, hydroxyl, -N(C1 - 4 alkyl)2, carbamoyl or C1- 4 alkoxy groups, an allyl group, a propargyl group, a C3 - 6 cycloalkyl group, a benzyl group, a phenyl group, or -NR1R2 represents a heterocyclic ring containing from 3 to 6 carbon atoms, or a C4 H4XN heterocyclic ring wherein X is O, S, CHOR' or N-R, R' being hydrogen or benzyl and R being hydrogen, a C1 - 4 alkyl group, or phenyl which is unsubstituted or substituted by methoxy or a halogen atom, provided that if Y is 6-chloro, A is not 4-chlorophenyl. |
