| 发明名称 |
ENTEROTOXIN MUTANT EFFECTIVE AS NONTOXIC ORAL STIMULATION AGENT |
| 摘要 |
medicine. SUBSTANCE: method involves applying mutant form of thermolabile enterotoxin of E. coli where arginine in position 192 is substituted with glycine that has lost its toxicity and retained its immunological activity. The enterotoxin is administered in combination with direct antigen for obtaining more pronounced immune response against the mentioned antigen when introduced as an ingredient of oral vaccine preparation. EFFECT: enhanced effectiveness of treatment. 18 cl, 5 dwg, 2 tbl
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| 申请公布号 |
RU2160606(C2) |
申请公布日期 |
2000.12.20 |
| 申请号 |
RU19970104479 |
申请日期 |
1995.07.18 |
| 申请人 |
DZE ADMINISTREJTORS OF DZE T'JULEJN EHD'JUKEJSHIONAL FAND |
发明人 |
DZHON D. KLEMENTS;BONNI L. DIKINSON |
| 分类号 |
C12P21/02;A61K38/00;A61K39/00;A61K39/02;A61K39/106;A61K39/108;A61K39/39;A61P31/04;A61P31/12;A61P31/16;A61P37/00;A61P37/04;C07K14/195;C07K14/245;C12R1/19;(IPC1-7):A61K39/00 |
主分类号 |
C12P21/02 |
| 代理机构 |
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| 地址 |
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