SURFACE DISPLAY OF SELENOCYSTEINE-CONTAINING PEPTIDES
摘要
The naturally-occurring amino acid selenocysteine (SEC) is incorporated uniquely and specifically in the context of a polypeptide displayed on the surface of an amplifiable genetic particle (phage, cell or spore) in response to incorporation signals engineered in the encoding DNA. In addition to conferring the unique activities of the selenol group to the chemistry of the displayed peptide, Sec also provides a unique handle for specific chemical modification of the display peptide. In addition to increasing the palette of available residues in a random peptide library to 21 possibilities, present invention also provides a means of tethering virtually any desired chemical functionality to the incorporated Sec.
申请公布号
WO0070100(A1)
申请公布日期
2000.11.23
申请号
WO2000US13292
申请日期
2000.05.12
申请人
NEW ENGLAND BIOLABS, INC.;SANDMAN, KAREN, E.;NOREN, CHRISTOPHER, J.