发明名称 |
HUMAN GLYCOSYLPHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE D VARIANTS AND USES THEREOF |
摘要 |
Glycosyl phosphatidy linositol specific phospholipase D (GPI-PLD) proteins and their medical uses are disclosed, in particular in the treatment and diagnosis of diabetes and complications of diabetes such as insulin resistance, liver dysfunction, disorders involving pancreatectomies and conditions mediated by a product of an infectious organism which is capable of inhibiting GPI-PLD, such as septic shock. The present invention further relates to variant GPI-PLD polypeptides modified at the phosphorylation site at amino acids 689-692 of the mature human wild-type protein.
|
申请公布号 |
WO0039285(A3) |
申请公布日期 |
2000.11.16 |
申请号 |
WO1999GB04399 |
申请日期 |
1999.12.23 |
申请人 |
UNIVERSITY COLLEGE LONDON;SCHOFIELD, JULIAN;RADEMACHER, THOMAS, WILLIAM |
发明人 |
SCHOFIELD, JULIAN;RADEMACHER, THOMAS, WILLIAM |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61K47/48;A61K48/00;A61P1/16;A61P1/18;A61P3/10;A61P7/00;A61P31/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/16;C12N9/20;C12Q1/02;(IPC1-7):C12N15/55;C12Q1/34;G01N33/48 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|