NITROGENOUS HETEROCYCLIC DERIVATIVES AND MEDICINE THEREOF

摘要

The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same. <CHEM> Wherein the ring A is an aromatic hydrocarbon ring which may have a heteroatom, the ring B represents (a) a saturated hydrocarbon ring, (b) an unsaturated hydrocarbon ring, (c) a saturated heterocyclic ring or (d) an unsaturated heterocyclic ring, all of which may have a substituent group, R<1> represents hydrogen atom, a halogen atom, a C1-6 alkyl group which may be substituted with a halogen atom, a C1-6 alkoxy group which may be substituted with a halogen atom, etc., R<2> and R<3> are the same as or different from and represent hydrogen atom, a C1-6 alkyl group which may have a substituent group, a C3-7 cycloalkyl group which may have a substituent group, etc., R<4>, R<5>, R<6> and R<7> are the same as or different from each other and each represent hydrogen atom, a halogen atom, a C1-6 alkyl group which may be substituted with a halogen atom, a C3-7 cycloalkyl group which may have a substituent group, a C1-6 alkoxy group which may have a substituent group, etc., neighboring R<3>, R<4>, R<5> and R<6> may be combined to form a ring which may be substituted with a C1-6 alkyl group which may contain a heteroatom, L represents a single bond, (a) a C1-6 alkylene group, (b) a C2-6 alkenylene group, (c) a C2-6 alkynylene group, all of which may have a substituent group, or a group represented by the formula -E-G- (wherein E represents oxygen atom, sulfur atom, the formula -CO-, -SO-, -SO2-, -N(R<8>)- (R<8> is hydrogen atom, a C1-6 alkyl group or an acyl group), -N(R<9>)-CO- (R<9> is hydrogen atom or a C1-6 alkyl group), or -(CH2)m- which may have a substituent group (m is an integer of 0 to 6), and G represents a sulfonyl group, the formula -N(R<10>)- (R<10> represents hydrogen atom, a C1-6 alkyl group or an acyl group) or -(CH2)n- (n is an integer of 0 to 6)), and X and Y are the same as or different from each other and each represents nitrogen atom, =CH- or a carbon atom which may be substituted with a C1-6 alkyl group which may have a substituent group, provided that X and Y are not simultaneously carbon atoms which may be substituted with a C1-3 alkyl group.