| 摘要 |
The present invention relates to methods for generating recombinant viruses from samples such as uncharacterised virus samples or clinical specimens, to the use of the viruses so generated in assays, predominantly for the purpose of detecting altered viral susceptibility to anti-viral drugs, and to reagents, more particularly deoxyribonucleic acid (DNA) vector constructs, for use in such methods and assays. The assays are adapted to detect resistant virus more accurately and sensitively than known assays by taking into account compensatory mutations arising in nucleotide sequences other than those encoding the anti-viral drug target.
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| 申请人 |
GLAXO GROUP LIMITED;BLAIR, EDWARD, DUNCAN;ROBINSON, LAURENCE, HENRY;SNOWDEN, BARBARA, WENDY;TISDALE, SYLVIA, MARGARET |
发明人 |
BLAIR, EDWARD, DUNCAN;ROBINSON, LAURENCE, HENRY;SNOWDEN, BARBARA, WENDY;TISDALE, SYLVIA, MARGARET |
