Optically active 1,4-dihydropyridine derivatives and process for the preparation thereof

摘要

PCT No. PCT/JP96/03414 Sec. 371 Date Aug. 21, 1998 Sec. 102(e) Date Aug. 21, 1998 PCT Filed Nov. 21, 1996 PCT Pub. No. WO97/30987 PCT Pub. Date Aug. 28, 1997Optically active 1,4-dihydropyridine derivatives represented by general formula (I) and anion salts thereof and a production method therefor: (wherein R1 represents a C1-6 alkyl group, R2 represents a nitrogen-containing heterocyclic group forming a quaternary ammonium which may be substituted, and n is an integer of 1, 2 or 3). The optically active 1,4-dihydropyridine derivatives represented by general formula (I) have vasodilating activity and hypotensive activity and are excellent in water solubility so that they are useful as a drug for circulatory system such as a hypotensor or vasodilator.