发明名称 |
Compositions for inhibiting platelet aggregation |
摘要 |
The invention is a pharmaceutical composition for oral administration to a patient comprising pharmaceutically effective amount of [3(R)-[2-Piperidin-4-yl)ethyl]-2-piperidone-1]acetyl-3(R)-methyl- beta -alanine, or a pharmaceutically acceptable salt thereof; pharmaceutically acceptable amounts of a polymeric binder; and pharmaceutically acceptable amounts of pharmaceutically acceptable excipients. The invention is also a process for making a pharmaceutical composition comprising [3(R)-[2-Piperidin-4-yl)ethyl]-2-piperidone-1]acetyl-3(R)-methyl- beta -alanine, which comprises the steps of a) mixing, in a vessel suitable for granulation, a pharmaceutically acceptable amount of [3(R)-[2-Piperidin-4-yl)ethyl]-2-piperidone-1]acetyl-3(R)-methyl- beta -alanine with pharmaceutically acceptable amounts of a pharmaceutically acceptable binder and with pharmaceutically acceptable amounts of pharmaceutically acceptable disintegrants and with pharmaceutically acceptable amounts of pharmaceutically fillers or diluents; b) adding a granulating fluid to the mixture during mixing of step a) to form granules; c) drying the granules to form dried granules; d) milling the dried granules to form milled granules; e) lubricating the milled granules to form lubricated granules; and f) compressing the lubricated granules into tablets.
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申请公布号 |
US6129932(A) |
申请公布日期 |
2000.10.10 |
申请号 |
US19980145871 |
申请日期 |
1998.09.03 |
申请人 |
MERCK & CO., INC. |
发明人 |
ASGHARNEJAD, MANDANA;SHIROMANI, PRAFULL K. |
分类号 |
A61K9/20;A61K31/4465;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/20 |
代理机构 |
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主权项 |
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地址 |
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