发明名称 |
Compounds enhancing antitumor activity of other cytotoxic agents |
摘要 |
This invention relates to certain heterocyclic compounds and their pharmaceutically acceptable salts, which are useful for sensitizing multidrug-resistant tumor cells to anticancer agents and multidrug resistant forms of malaria, tuberculosis, leishmania and amoebic dysentery to chemotherapeutants. The compounds and their pharmaceutically acceptable salts are also inhibitors of the active drug transport capability of P-glycoprotein which is encoded by the human MDR1 gene, as well as of certain other related ATP-binding-cassette transporters from eukaryotic and prokaryotic organisms (e.g., pfmdr from Plasmodium falciprum, and murine mdr1 and mdr3 gene products).
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申请公布号 |
US6130217(A) |
申请公布日期 |
2000.10.10 |
申请号 |
US19950513880 |
申请日期 |
1995.09.20 |
申请人 |
PFIZER INC |
发明人 |
ARNOLD, LEE DANIEL;COE, JOTHAM WADSWORTH;KANEKO, TAKUSHI;MOYER, MIKEL PAUL |
分类号 |
C07D235/30;C07D277/82;(IPC1-7):A61K31/495;C07D417/12;C07D417/14;C07D403/12 |
主分类号 |
C07D235/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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