IN VITRO AND IN VIVO MODELS FOR SCREENING COMPOUNDS TO PREVENT GLUCOCORTICOID-INDUCED BONE DESTRUCTION
摘要
The present invention demonstrates that glucocorticoid-induced bone disease is due to changes in the birth and death rate of bone cells using a murine model of glucocorticoid excess as well as bone biopsy specimens obtained from patients with glucocorticoid-induced osteoporosis. This invention demonstrates that glucocorticoid administration increases apoptosis of mature osteoblasts and osteocytes and decreases bone formation rate and bone mineral density accompanied by defective osteoblastogenesis and osteoclastogenesis in the bone marrow.
申请公布号
WO0020625(A9)
申请公布日期
2000.10.05
申请号
WO1999US23395
申请日期
1999.10.07
申请人
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS