MHC binding peptide oligomers

摘要

Oligomers comprising at least two MHC binding peptides joined by a flexible molecular linker and an oriented cloning method for producing the oligomers. The oligomers can be used in connection with methods for specifically activating or inhibiting the activation of CD4+ or CD8+ T cells. Such methods provide therapeutic approaches for the treatment of tumours, autoimmune disorders, allograft rejection and allergic reactions.