| 摘要 |
PCT No. PCT/SE96/01091 Sec. 371 Date Apr. 17, 1998 Sec. 102(e) Date Apr. 17, 1998 PCT Filed Sep. 3, 1996 PCT Pub. No. WO97/14408 PCT Pub. Date Apr. 24, 1997A method of preparing parenterally administrable sustained release microparticles, which comprises preparing core particles in an aqueous medium that is essentially free from organic solvent, a biologically active substance being entrapped therein during or after said preparation, drying the core particles and coating the same with a release-controlling polymer by air suspension technique so as to create a shell on the core particles without any detrimental exposure of the active substance to organic solvent. Microparticles obtainable by such a method also are provided.
|
