发明名称 |
HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS |
摘要 |
The present invention is directed to compounds of Formula (I) wherein X is O , S or NR7 and R1-R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula (I). The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.
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申请公布号 |
CA2362390(A1) |
申请公布日期 |
2000.08.17 |
申请号 |
CA19992362390 |
申请日期 |
1999.08.11 |
申请人 |
3-DIMENSIONAL PHARMACEUTICALS, INC. |
发明人 |
ILLIG, CARL R.;HOFFMAN, JAMES B.;SUBASINGHE, NALIN L.;WILSON, KENNETH J.;RUDOLPH, M. JONATHAN;MARUGAN, JUAN JOSE |
分类号 |
A61K31/381;A61K31/403;A61K31/4178;A61K31/422;A61K31/427;A61K31/4436;A61K31/4439;A61K31/454;A61K31/4709;A61K31/496;A61K31/506;A61K31/5377;A61K31/745;A61P1/18;A61P9/10;A61P11/00;A61P15/00;A61P17/02;A61P19/06;A61P25/16;A61P25/28;A61P35/00;A61P35/04;A61P43/00;C07D333/38;C07D409/04;C07D409/12;C07D413/04;C07D417/04;C07D417/12;C07D417/14;(IPC1-7):C07D417/04;A61K31/426 |
主分类号 |
A61K31/381 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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