发明名称 |
PATTERNED BINDING OF FUNCTIONALIZED MICROSPHERES FOR OPTICAL DIFFRACTION-BASED BIOSENSORS |
摘要 |
The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
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申请公布号 |
WO0034781(A3) |
申请公布日期 |
2000.08.17 |
申请号 |
WO1999US27671 |
申请日期 |
1999.11.22 |
申请人 |
KIMBERLY-CLARK WORLDWIDE, INC. |
发明人 |
EVERHART, DENNIS, S.;KAYLOR, ROSANN, M.;MCGRATH, KEVIN |
分类号 |
C40B60/14;G01N21/47;G01N33/543;G01N33/553;(IPC1-7):G01N33/553;B41M3/00 |
主分类号 |
C40B60/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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