New heteroaromatic compounds, useful e.g. in the treatment of Parkinson's, Alzheimer's and Huntington's diseases, stimulate neurite growth

摘要

Heteroaromatic compounds (I) and their salts are new. Heteroaromatic compounds of formula (I) and their salts are new. R<1> = H, Ar', 1-7C alkyl, 2-7C alkenyl, 3-7C cycloalkyl or 5-7C cycloalkenyl (all optionally substituted by Ar' or E); Y' = C(O)C(O), SO2, -C(O)NH-, -C(S)NH--, C(O)C(O)O, C(O)C(O)NH, C(O)O or SO2NH; R<2> = 1-6C alkyl (optionally substituted by phenyl or halogenated phenyl); R<3> = 1-6C alkyl, 2-6C alkenyl, 3-7C cycloalkyl, 5-7C cycloalkenyl, cyclohexylmethyl (all optionally substituted by 1 - 2 Ar'); or NR<2>R<3> = 5-7 membered heterocyclyl (optionally unsaturated and optionally substituted by 1-4C alkyl or OH); X = 5-membered heteroaryl with 1 - 3 N, O or S; R<4> = 1-9C alkyl or 2-9C alkenyl (both optionally substituted by 1 - 2 Ar', 3-7C cycloalkyl or 5-7C cycloalkenyl), Ar', 3-7C cycloalkyl or 5-7C cycloalkenyl; Ar' = 6-12C mono- or bicyclic aromatic compound containing 0 - 4 N, S or O and optionally partially hydrogenated and optionally substituted by 1 - 3 E; E = halogen, OH, NO2, CF3, CN, OCF3, NH2, phenyl, methylenedioxy, phenoxy, benzyloxy, 1-4C alkoxy or 1-4C alkyl. Independent claims are also included for: (1) a pharmaceutical agent containing (I) a neurotrophic factor; and (2) preparation of (I).