PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE AMINO ALCOHOLS

摘要

3 process for the preparation of optically active beta -amino alcohols represented by the general formula (2): Ra-C*H(OH)-C*H(Rb)-Rc, [wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, or the like; Rb is one member selected from among groups represented by the following general formulae: (3) R1CO(R2)N-, (4) R1CO(R1'CO)N-, (5) R1CO(R1'SO2)N-, (6) R1SO2(R2)N- (wherein R1, R1' and R2 are each independently hydrogen, optionally substituted alkyl, or the like, or alternatively R1 and R2 or R1 and R1' may be united to form a five- to eight-membered nitrogenous heterocycle); and C* is an asymmetric carbon atom], characterized by reacting a racemic alpha -aminocarbonyl compound represented by the general formula (1): Ra-CO-CH(Rb)-Rc (wherein Ra, Rb and Rc are each as defined above) with hydrogen or a hydrogen donor in the presence of an optically active transition metal compound and a base.