发明名称 |
Small molecular weight ligand-hexose containing clearing agents |
摘要 |
Small molecule weight clearing agents containing ligands such as biotin or biotin analogs and hexose residue, in particular galactose or N-acetyl galactosamine residues are taught. These clearing agents effectively clear anti-ligand containing conjugates in vivo via hepatocyte receptor mediated clearance mechanisms.
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申请公布号 |
US6075010(A) |
申请公布日期 |
2000.06.13 |
申请号 |
US19940350551 |
申请日期 |
1994.12.07 |
申请人 |
NEORX CORPORATION |
发明人 |
THEODORE, LOUIS J.;AXWORTHY, DONALD B.;RENO, JOHN M. |
分类号 |
A61K47/48;A61K51/04;A61K51/12;C07D495/04;(IPC1-7):A01N43/04;A61K31/70 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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