COMPOSITIONS COMPRISING ANGIOSTATIN AND KRINGLE 5 REGION OF PLASMINOGEN AND METHODS OF USE THEREOF

摘要

The present invention relates to one or more compositions that inhibit the proliferation and/or migration of endothelial cells. The compositions contai n a kringle 5 region of plasminogen and/or Angiostatin. If two separate compositions are used, one containing a kringle 5 region of plasminogen, or a biologically active portion thereof, and the other containing Angiostatin, t he compositions may be administered sequentially or simultaneously. The compositions are useful to treat angiogenic associated disorders.