| 摘要 |
This invention relates to certain 3-aminomethylpyrrolidine derivatives of Formula (I), wherein: Z is -N- or -(N<+>r)- X<-> wherein R is alkyl, haloalkyl, aralkyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, or cyanoalkyl, and X<-> is a pharmaceutically acceptable counterion; Ar<1> and Ar<2> are, independently of each other, aryl or heteroaryl; Q is straight or branched alkylene with 1-3 carbon atoms; R<1> is hydrogen or alkyl; A is either: (I) -N(R<2>)C(O)- when: B is: (i) an alkylene with 1-4 carbon atoms inclusive wherein one of the carbon atoms may optionally be replaced by a group selected from -C(O)-, -N(R<4>)-, -O-, -S(O)n- (where n is 0, 1 or 2), -NR<5>C(O)- and -N(R<6>)SO2-; or (ii) an alkynylene chain; or (II) a group selected from -N(R<2>)C(S)-, -N(R<2>)C(O)N(R<3>)-, -N(R<2>)C(S)N(R<3>)-, -N(R<2>)SO2-, -N(R<2>)SO2N(R<3>)-, -N(R<2>)C(O)O-, and -OC(O)N(R<3>)- when: B is: (i) a bond; (ii) an alkylene chain of 1-4 carbon atoms inclusive wherein one of the carbon atoms may optionally be replaced by a group selected from -C(O)-, -N(R<4>)-, -O-, -S(O)n- (where n is 0, 1 or 2), -NR<5>C(O)- and -N(R<6>)SO2-; (iii) an alkenylene chain; or (iv) an alkynylene chain; that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
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