OSTEOPLASTIC GRAFT

摘要

A bone-forming graft which comprising a bone morphogenetic protein carried on a composite porous body, said composite porous body comprising a porous frame of a bioabsorbable hydrophilic material and a surface layer of a bioabsorbable polymer material. In particular, the present invention relates to a bone-forming graft in which the bioabsorbable hydrophilic material is one or more compounds selected from a group consisting of gelatin, hyaluronic acid, a hyaluronic acid derivative, collagen, a collagen derivative, chitosan, a chitosan derivative, and triethanolamine alginate, and the bioabsorbable polymeric material is one or more compounds selected from a group consisting of a polylactic acid, a copolymer of a polylactic acid and a polyglycolic acid, and a copolymer of polyÄbis(p-carboxyphenoxy)propaneÜanhydride and sebacic acid. As the graft is excellent in formability and workability and has an internal structure suitable for in vivo bone formation, bone formation occurs not only at the periphery of the graft but also within the graft.