| 摘要 |
<p>The invention relates to a Steroid Receptor RNA Activator (termed SRA) which acts as a steroid hormone receptor coactivator and to the detection of RNA transcripts capable of transactivation of a DNA sequence. The use of SRA to detect protein/RNA interactions including the specific situation of RNA/protein interactions for transactivation of heterologous promoters is described. Methods to evaluate or modulate type I or 'classical' nuclear receptors are also described. Furthermore, SRA and its expression levels can facilitate design and evaluation of agents capable of modulating its levels or interactions with other proteins. It also relates to the levels of SRA expression facilitating detection, prognosis or treatment of steroid-dependent tumors or to the detection of prenatal or postnatal cortisol resistance. Finally, SRA expression patterns can be utilized to detect steroid receptor expression patterns.</p> |
