Stable combination of 14,17-over-bridged steroid gestagen and cyclodextrin compound, useful for treating climacteric disorders or for contraception

摘要

Novel combinations comprise (A) at least one gestagen selected from 14,17-over-bridged steroids and (B) at least cyclodextrin (CD) compound selected from beta -CD, psi -CD and their derivatives in which free alcohol functions are etherified or esterified. Independent claims are included for (i) a method for stabilizing (A) using (B), (ii) a method for complexing (A) with beta -CD or /=-CD, by trituration as a dry blend or by precipitation reaction, preferably co-precipitation and (iii) a method for the direct tableting of a complex of (A) with beta -CD or psi -CD, with addition of pharmaceutical auxiliaries.