| 摘要 |
New and structurally distinct ultrasound contrast agents that comprise micron size microbubbles encapsulating a gas within a shell made from a blend of bipolar compounds having inter-molecular hydrophobic regions of mixed carbon chain length. The compounds have the following structure: R>1<-X-Z; R>2<-X-Z; and R>3<-X-Z', where R>1<, R>2< and R>3< are hydrophobic groups selected from the group consisting of straight-chained alkyls, alkylethers, alkylthiolethers, alkyldisulfides, polyfluoroalkyls, and polyfluoroalkylethers having a carbon chain length greater than or equal to 16 and less than or equal to 32 and where R>1< is greater than R>2< and R>1< is greater than or equal to R>3<; R>3< has one or more such hydrophobic groups having the same or different lengths; X is a linker connecting the hydrophobic group to the polar head group; Z is a polar head group selected from the group consisting of CO>2<-M?+>, SO3<->M<+>, SO4<->M<+>, PO3<->M<+>, PO4<->M<+>2, N(R)4<+>, a pyridinium or substituted pyridinium group, and a zwitterionic group; R is selected from the group consisting of -H, -CH3, alkyl, cycloalkyl, substituted cycloalkyls containing one or more heteroatoms, and benzyl and can be the same or different; and Z' is a nonionic group.
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