Flexible bottom culture plate for applying mechanical load to cell cultures

摘要

A cell culture plate having a flexible membrane sandwiched between a base and a body. Each of the base and body have a plurality of mutually aligned openings. A wall surrounds each opening in the body thereby forming a cell culture well with a portion of the membrane functioning as the floor of the well. When a pressure differential is applied to the underside of the membrane, the membrane stretches, inducing strain on cells cultured thereon. The cell culture plate is sealingly positioned within a recess of a baseplate. An opening defined in the recess communicates with a pressure supply and provides fluid access to the cell culture plate underside to induce the pressure differential thereon.