THIAZOLIDENEDIONES ALONE OR IN COMBINATION WITH OTHER THERAPEUTIC AGENTS FOR TUMOR THERAPY

摘要

A purpose of the present invention is to identify and/or develop nontoxic or low toxic chemotherapeutic regiments to treat cancer. Prototype cells tested are derived from an osteosarcoma from an eleven year girl who died after aggressive chemotherapeutic treatment with adriamycin, vincristine, cytoxan, and aramycin-C. The inventive steps described herein include demonstrating that troglitazone inhibits cell proliferation in human osteosarcoma cells, the presence of functional PPAR- gamma in such cells, and the demonstration of the ability of troglitazone to lower the IC50 of other chemotherapeutic agents such as 5-fluorouracil and doxorubicin when administered in combination therewith as regarding cell proliferation.