Benzimidazole derivative, hair growth promoter and external composition for skin using the same

摘要

A benzimidazole derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R<1> and the other is -(CH2)n-NR<2>R<3>; R<2> and R<3> individually represent H, lower alkyl, phenyl or benzyl, or -NR<2>R<3> may be a heterocycle having 3-7 members, or -CONR<5>-(CH2)n-NR<2>R<3> may be the following Group (W): wherein R<2> is H, lower alkyl, phenyl or benzyl and ring E is a heterocycle of 6 or 7 members; R<4> is selected from the group consisting of H, halogen, cyano, trifluoromethyl, lower alkyl and etc.; R<5> is H, lower alkyl, lower acyl or lower alkylcarbamoyl; m is 0 or 1; and n is an integer of 0-5. The benzimidazole derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.