发明名称 |
QUICK RELEASE PHARMACEUTICAL COMPOSITIONS OF DRUG SUBSTANCES |
摘要 |
The present invention relates to an oral modified release pharmaceutical composition for the administration of a therapeutically and/or prophylactically effective amount of an active substance (a drug substance) to obtain a relatively fast or quick onset of the therapeutic and/or prophylact ic effect. The drug substances contained in a modified release pharmaceutical composition according to the invention are suitably a drug substance which h as a very low solubitity under acidic conditions, i.e. under conditions similar to those present in the stomach and/or drug substances which have a pKa valu e below about 5.5 such as in a range of from about 4 to about 5. The compositi on is based on a powder comprising a therapeutically and/or prophylactically active substance and has such a particle size that: when the powder is subjected to a sieve analysis, then at least about 90 % w/w of the particles passes through sieves 180 .mu.m and the powder is contacted with an aqueous medium to form a particulate composition, which has such a particle size tha t when the particulate composition is subjected to a sieve analysis, then at least about 50 % w/w of the particles passes through sieve 180 .mu.m. Furthermore, the composition, when tested in accordance with the dissolution method (I) defined herein employing 0.07 N hydrochloric acid as dissolution medium, releases at least about 50 % w/w of the active substance within the first 20 min of the test.
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申请公布号 |
CA2343148(A1) |
申请公布日期 |
2000.03.23 |
申请号 |
CA19992343148 |
申请日期 |
1999.09.10 |
申请人 |
NYCOMED DANMARK A/S |
发明人 |
BERTELSEN, POUL;ITAI, SHIGERU;RUCKENDORFER, HERMANN;HANSEN, NILS GJERLOV |
分类号 |
A61K9/14;A61K9/16;A61K9/20;A61K9/28;A61K9/48;A61K31/542;A61K33/10;A61K33/12;A61K45/00;A61K47/02;A61K47/04;A61K47/26;A61P1/04;A61P5/46;A61P25/04;A61P25/24;A61P29/00;A61P43/00;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/14 |
代理机构 |
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主权项 |
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地址 |
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