| 发明名称 |
TREATMENT OF CELIAC DISEASE WITH INTERLEUKIN-15 ANTAGONISTS |
| 摘要 |
The invention relates to the treatment of inflammatory bowel diseases, such as celiac disease with interleukin-15 (IL-15) antagonists. Preferably the antagonists are muteins of IL-15, antibodies against IL-15 or IL-15 molecules bound to chemical groups that interfere with the ability of IL-15 to effect a signal transduction through either the beta or gamma -subunit of the IL-15 receptor complex, but which do not interfere with IL-15 binding to IL-15R alpha . |
| 申请公布号 |
WO0002582(A3) |
申请公布日期 |
2000.03.16 |
| 申请号 |
WO1999GB02201 |
申请日期 |
1999.07.09 |
| 申请人 |
THE MATHILDA AND TERENCE KENNEDY INSTITUTE OF RHEUMATOLOGY;LONDEI, MARCO;QUARATINO, SONIA;MAIURI, LUIGI |
发明人 |
LONDEI, MARCO;QUARATINO, SONIA;MAIURI, LUIGI |
| 分类号 |
A61K47/48;A61K38/00;A61K38/20;A61K39/395;A61K45/00;A61P1/00;A61P31/00;A61P43/00;C07K16/24;(IPC1-7):A61K38/20;A61K9/02;A61K9/20 |
主分类号 |
A61K47/48 |
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