APOPTOSIS INDUCING AGENTS

摘要

Apoptosis inducing agents which contain as the active ingredient tetrocarcin derivatives represented by general formula (I) or salts thereof. These agents are useful as drugs for preventing and/or treating diseases caused by the accelerated expression of proteins of the Bc1-2 family such as cancer and AIDS; wherein --- represents a single or double bond; j and k are each 0 or 1; R<1> to R<3>, R<7> to R<10> and R<14> represent each hydrogen, lower alkyl, etc.; R<4>, R<11>, R<12>, R<13> and R<15> to R<18> represent each hydrogen, hydroxy, lower alkyl, etc.; R<5> and R<6> represent each hydrogen, hydroxy, lower alkyl or (B) (wherein R<32> represents formyl, etc.; and R<33> to R<35> represent each hydrogen, hydroxy, lower alkyl, etc.); and R<19> represents hydroxy, lower alkoxy, lower alkanoyloxy, etc.