| 摘要 |
Recombinant, isolated, enriched or cell free protein having activity as a proton activated receptor when expressed in, inter alia, mammalian dorsal root ganglion cells; to DNA and RNA encoding for expression of such protein in cells; cells containing this DNA and/or RNA and which express the protein in a form that is activatable by protons and its agonist analogues whereby the proteins exhibits electrophysiological and pharmacological properties characteristic of ASIC beta and ASIC gamma proton-gated cation channels; and DNA and RNA designed to downgrade expression of this protein for the purpose of gene therapy of pH mediated pain or disorders. |
