Process for covalently coupling organic compounds utilizing diboron derivatives for preparation of an aryl boronic acid

摘要

The invention provides a process for covalently coupling organic compounds which comprises reacting an aromatic ring compound having a halogen or halogen-like substituent at a coupling position with a diboron derivative in the presence of a Group VIII metal catalyst and a suitable base. The invention also provides useful arylboron intermediates. Substituted bi and tri-aryl compounds are of great interest to the pharmaceutical and agrochemical industries. A great number of these compounds have been found to possess pharmaceutical activity, while others have been found to be useful herbicides. There is great interest from the polymer industry in polymers prepared by linking together of aromatic ring compounds.