| 摘要 |
This invention relates to the prophylaxis of choroidal neovascularisation in macular degeneration by the introduction of a suitable anti-inflammatory age nt into the vitreous. In particular, it relates to the prophylaxis of neovascularisation with an anti-inflammatory steroid, such as an 11- substituted 16.alpha.,17.alpha.-substituted methylenedioxy steroid of formul a (I) wherein (a) is (b), (c), (d), (e), (f), (g), (h), (i), (j), (k) or (l); R1 and R2 are hydrogen or alkyl; -Ca-Cb- is -CH2-CH2-, -CH=CH-, (m) or (n); R3 is methyl, hydroxymethyl or alkylcarbonyloxymethyl, methylaminoalkylenecarbonyloxymethyl, or phenylaminoalkylenecarbonyloxymethy l; R4 is alkanoyl; and X is halogen in eyes which have been identified as havin g a high risk of developing choroidal neovascularisation. More particularly, i t relates to prophylaxis with triamcinolone acetonide, (compound II).
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