| 摘要 |
Methods, pharmaceutical compositions and kits are provided for inducing programmed cell death in cells expressing the E6 oncogene. The methods and compositions are particularly suited for treatment of cancers involving infections with E6-expressing virus, such as human papilloma virus (HPV). The methods and compositions utilize the p53 homolog, p73. Unlike p53, p73 is not targeted by the E6 oncoprotein for ubiquitin-mediated degradation, and so provides a viable alternative to p53 therapy for treatment of E6-expressing cancers. |
