Glucagon-like peptide and insulinotropin derivates

摘要

This invention relates to derivatives of glucagon-like peptide 1 (GLP-1), truncated GLP-1, insulinotropin and truncated insulinotropin which have a pl of about 4.0 or less or a pl of about 7.0 or greater. The derivatives of GLP-1, truncated GLP-1, insulinotropin and truncated insulinotropin within the scope of this invention are particularly suited for delivery to a mammal by iontophoresis. This invention also relates to methods for enhancing insulin action in a mammal with said derivatives and to pharmaceutical compositions comprising said derivatives. Further still, this invention relates to new uses of certain known derivatives of insulinotropin and truncated insulinotropin to enhance insulin action in a mammal by iontophoretic administration of such derivatives.