摘要 |
DD-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing DD-1 polypeptides and polynucleotides in the design of protocols for the treatment of neurodegenerative disorders (including Alzheimer's disease, Parkinson's disease, cerebellar degeneration, and amyotrophic lateral sclerosis), ischemic injury (including stroke, myocardial infarction, and reperfusion injury), AIDS, aplastic anemia, polycistic kidney disease, osteoporosis, chronic degenerative liver disease, cancer, autoimmune disorders (including systemic lupus erythematosus and immune-mediated glomerulonephritis), viral infections, and rheumatoid arthritis, among others, and diagnostic assays for such conditions. |